Versatility of USP18 in physiology and pathophysiology

Physiology And PAthoPhysiology of AquAPorins

Received 2 July 2010, accepted 1 August 2010. Correspondence to: Dr Amaia Rodríguez, Metabolic Research Laboratory, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain. Tel.: +34 948 42 56 00 (ext. 6544), Fax: +34 948 42 56 52, E-mail: [email protected] Abstract Aquaporins (AQPs) are water channels that facilitate a rapid transport of water, across cell membranes. in some cases, these pore...

Physiology and pathophysiology of eryptosis.

SUMMARY Suicidal erythrocyte death (eryptosis) is characterized by cell shrinkage, cell membrane blebbing, and cell membrane phospholipid scrambling with phosphatidylserine exposure at the cell surface. Eryptotic cells adhere to the vascular wall and are rapidly cleared from circulating blood. Eryptosis is stimulated by an increase in cytosolic Ca(2)+ activity, ceramide, hyperosmotic shock, oxi...

Physiology and pathophysiology of aquaporins.

Physiology and pathophysiology of carnosine.

Carnosine (β-alanyl-l-histidine) was discovered in 1900 as an abundant non-protein nitrogen-containing compound of meat. The dipeptide is not only found in skeletal muscle, but also in other excitable tissues. Most animals, except humans, also possess a methylated variant of carnosine, either anserine or ophidine/balenine, collectively called the histidine-containing dipeptides. This review aim...

HIGHLIGHTED TOPIC Pulmonary Physiology and Pathophysiology in Obesity Pulmonary physiology and pathophysiology in obesity

OBESITY is now a common occurrence in modern society. Barely one-third of Americans fall into the normal weight range, and 32% of the population has been classified as obese (9). The obesity epidemic is permeating into the childhood years, with 16.3% of children in the United States being above the 95th percentile for the body mass index (BMI), resulting in comorbidities such as the metabolic s...